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Jul-03-2014

MDPlus Line of Supplements are 100% Safe for Drug Tested Athletes

I get questions about my line of supplements from drug tested athletes all the time. And as a former drug tested elite athlete in Powerlifting I can certainly empathize. As an example, I’ve copied a recent correspondence from an athlete who was questioning LipoFlush Extreme as far as possibly resulting in a positive drug test. My supplements are all manufactured by GMP Labs, a pharmaceutical level facility - – link is http://www.gmplabs.com/. Info on their NSF certification is at http://www.gmplabs.com/index.cfm/41013/17497/gmp_labs_gains_nsf_certified_for_sport_registration and GMP certification at http://www.gmplabs.com/index.cfm/41013/17499/gmp_laboratories_of_america_aces_cgmp_audit. Both the ingredients and finished products are tested to make sure there are no contaminants and what’s in them is all that’s in them at the dosages on the nutritional panel.

 

Besides the analytical and manufacturing side, there’s the fact that thousands of drug tested athletes use or have used my supplements and none have ever tested positive. The bottom line is that I’m in charge of all aspects of my nutritional supplement company, constantly formulating and researching all aspects of nutrition and drug testing, and I’m fanatical to make sure that none of the ingredients in my products are WADA/IOC compliant. As such you can be 100% sure that using any/all of my supplements will not result in a positive drug test. This includes the new Metabolic, which will be out in a month or so and which no longer contains DHEA, a move I made to make my complete supplement line compliant with USADA/WADA/IOC drug testing guidelines and protocols.

 

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Athlete's Question: I’m a drug tested athlete who has been using your LipoFlush for a few years now. It’s a great product as it not only keeps my body fat levels down without me having to lose muscle mass but also gives me loads of energy for training and has improved my performance. However, recently I was told by my coach that the new LipoFlush Extreme contains a substance that is banned by WADA/IOC and will cause a positive drug test. That substance is citrus aurantium.

 

 I was at a loss at how to respond as I’ve been tested several times while on LipoFlush and never tested positive. On the other hand even though I’ve never tested positive I need some assurance that I won’t test positive in future drug tests using the new LipoFlush Extreme as against the former version of LipoFlush version III.

 

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Let me reassure you that you won’t test positive taking the new LipoFlush Extreme even though it does contain citrus aurantium. Also I think it’s important that you know that former versions of LipoFlush all contained citrus aurantium. Your coach isn’t all wrong but he is wrong about citrus aurantium being banned by WADA and that it causes a positive drug test. As this is an important issue for drug tested athletes I’ll explain in some detail why it’s safe to use LipoFlush Extreme version IV, and for that matter all former versions of LipoFlush, and why LipoFlush Extreme version IV won’t cause a USADA/WADA/IOC positive drug test.

 

First of all LipoFlush and all my line of nutritional supplements are produced in a lab that is NSF certified, and therefore doesn’t use any ingredients that are banned by WADA. As such, at this time every product in my line of supplements is safe for drug tested athletes to use, even Metabolic, which until I reformulated it contained DHEA, but doesn’t any more. Having said that your coach is misinformed in that citrus aurantium per se is not banned by WADA.

                                               

The three main ingredients in citrus aurantium are N-methyltyramine (tyramine), octopamine and synephrine. Of the three synephrine, which is by far the most dominant alkaloid, is not banned but is monitored in competition only, as is caffeine and some other stimulants. As per WADA – “The following substances included in the 2014 Monitoring Program (bupropion, caffeine, nicotine, phenylephrine, phenylpropanolamine, pipradol, synephrine) are not considered as Prohibited Substances.”

 

For info go to http://www.wada-ama.org/Documents/World_Anti-Doping_Program/WADP-Prohibited-list/2014/WADA-Monitoring-Program-2014-EN.pdf, http://www.wada-ama.org/en/world-anti-doping-program/sports-and-anti-doping-organizations/international-standards/prohibited-list/monitoring-program/ and http://www.wada-ama.org/Documents/World_Anti-Doping_Program/WADP-Prohibited-list/2014/WADA-prohibited-list-2014-EN.pdf

 

Octopamine is banned by the IOC (only during competitions but not at other times) as a stimulant but only in significant levels in urine that are indicative of significant exogenous use of octopamine. That’s because octopamine is an endogenous substance (naturally found in the body) and is also found in small amounts naturally in certain foods and ingredients including a wide range of natural 'orange based' food products such as freshly squeezed orange juice, marmalades, orange squash, etc. as well as citrus aurantium, also called bitter orange, and in other food types including fish sauce and meat products.

 

Citrus aurantium (bitter orange) is a plant derived ingredient that has extremely low levels of octopamine, and even at many times the dosage found in citrus aurantium, not enough to trigger an anti-doping violation. Information from the WADA Science Director confirms that people consuming bitter orange even at relatively high levels will not produce urinary octopamine above the reportable level and this is reflected by the doping lab statistics.

 

The bottom line is that the amount of octopamine in one dose of LipoFlush is less than in a small glass of freshly squeezed orange juice and cannot result in a positive drug test. FYI I’ve copied abstracts of a few studies below. The first abstract is a study that found that there was no elevation of urinary octopamine with the use of dietary supplements. Octopamine taken as a drug however, did raise urinary levels above the baseline levels that WADA allows in the urine.

 

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Biomed Chromatogr. 2012 May;26(5):610-5. doi: 10.1002/bmc.1705. Epub 2011 Sep 19. Analysis of octopamine in human doping control samples. Thevis M1, Koch A, Sigmund G, Thomas A, Schänzer W. Abstract The biogenic amine octopamine [4-(2-amino-1-hydroxyethyl)phenol] is prohibited in sports owing to its stimulating and performance-enhancing properties. Adverse analytical findings in athletes' doping control samples commonly result from surreptitious applications; however, the occurrence of octopamine in nutritional supplements and in selected invertebrates as well as the assumption that its N-methylated analog synephrine [4-(1-hydroxyethyl-2-methylamino)phenol, not banned by anti-doping authorities but currently monitored in prevalence studies) might be converted in-vivo into octopamine have necessitated a study to investigate the elimination of synephrine and octopamine present in over-the-counter products. Urine samples collected after administration of nutritional supplements containing octopamine and/or synephrine as well as urine samples collected after therapeutic application of octopamine- or synephrine-containing drugs were analyzed using a validated solid-phase extraction-based procedure employing a weak cation exchange resin and liquid chromatographic/tandem mass spectrometric detection with electrospray ionization and multiple reaction monitoring.

 

In the case of therapeutic octopamine application, the urinary concentration of the target compound increased from baseline levels below the lower limit of detection to 142 µg/mL, while urine samples collected after synephrine as well as dietary supplement administration did not yield any evidence for elevated renal excretion of octopamine.

 

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J Sep Sci. 2011 May 9. doi: 10.1002/jssc.201100186. [Epub ahead of print] Separation of adrenergic amines in Citrus aurantium L. var. amara by capillary electrochromatography using a novel monolithic stationary phase. Chizzali E1, Nischang I, Ganzera M. Abstract This manuscript reports on the use of capillary electrochromatography for the determination of tyramine, (±) synephrine, and (±) octopamine, the major alkaloids in bitter orange peel. A novel methacrylate-based monolithic stationary phase was prepared by UV-photopolymerization in 100?µm id fused-silica capillaries. It facilitated the quantitative assessment of alkaloids with a mobile phase comprising aqueous 10?mM ammonium acetate in ACN and isopropanol. Applied voltage and temperature were 25?kV and 25°C, and samples were injected in electrokinetic mode. The method reported herein revealed adequate sensitivity (LOD =0.6?µg/mL), repeatability (s(rel) =4.1%), accuracy (recovery rates between 95.2 and 102.2%), and precision (intra-day variation =5.7%, inter-day variation =4.1%). The application of the CEC assay on C. aurantium var. amara plant material and dietary supplements, which usually are advertised for slimming properties, indicated that synephrine (0.17-0.82%) is the dominant alkaloid.

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