LipoFlush Version III
Research Driven Fat Loss Formula
LipoFlush III represents a quantum leap in fat loss supplements. It's the first supplement on the market that effectively decreases body fat by working at all the relevant metabolic, absorption and excretion levels, while at the same time providing substantial health benefits.
LipoFlush is a research-driven, synergistic blend of natural ingredients are designed to dramatically decrease body fat, increase energy levels, preserve skeletal muscle, and provide major health benefits.
While other fat loss supplements work on one or at the most two dimensions of the fat loss equation, LipoFlush attacks fat from several independent and synergistic ways, resulting in unprecedented fat loss.
One of these ways, not available in any other fat loss supplement, will literally flush the fat right out of your body.
Like liposuction, LipoFlush can make some of your fat simply disappear, but unlike liposuction, LipoFlush can do it in the problem areas and also evenly all over your body, leaving you with an aesthetic looking body with just the right look.
LipoFlush, unlike the old ephedra based and all the present weight and fat loss formulas, improves your health and provides a natural energy boost. Because of the multi-step way LipoFlush approaches fat loss, some of the fat loss effects take place 24 hours a day work even while you’re sleeping. On top of all this it protects muscle so that when you lose weight it's almost 100% fat.
But that’s not all. LipoFlush is not only useful in getting rid of unwanted fat, it also helps you to keep it off. There are several ingredients in LipoFlush that counteract the rapid increase in weight and body fat that happens when you go off most diets.
Weight Loss versus Fat Loss
Weight loss is an oxymoron. Who really wants to just lose weight? That means losing weight from all of the various tissues in your body, including muscle and bone.
That’s not what people want when they say they want to lose weight. What they really want to lose is FAT, not muscle. After all maintaining or even increasing muscle mass not only makes the body look and function better, but it makes it easier to lose body fat and keep it off.
It’s important to realize that fat loss is not simply a matter of exercising more and eating less, although these are part of the fat loss equation. Effective fat loss also means guiding your body down the right metabolic paths where you target fat breakdown and spare muscle.
It’s also more than just breaking down body fat. You also have to do something with that body fat so it doesn’t simply reform. That means getting rid of it by increasing the burning of this fat for fuel and flushing some of it right out of the body.
Simple as that sounds, it’s not what most weight and fat loss supplements do. Many of the formulations on the market today, including the once popular ECA stack (combinations of ephedra, caffeine and ASA) formulations, will increase fat breakdown (lipolysis) but do not dispose of this fat efficiently and in most cases the fat is reformed and just goes right back to the same body areas. Also the weight loss and fat loss formulations miss the mark when it comes to using cutting edge research studies to solve the fat loss equation.
Besides increasing lipolysis and making sure you get rid of that released fat, it's also important to make sure that the weight you lose is fat and not muscle. Cutting calories can lead to weight loss but some or even most of this weight loss may in fact represent muscle and other tissues. The trick to losing weight is to lose mostly fat so that when you’re down to your target goal you look and feel good.
It’s also important to keep making progress. Anyone can lose weight at first but it’s a real challenge to keep it up. That’s because your body reacts to the imagined threat of starvation by instituting some ages old survival mechanisms, mainly slowing the metabolic rate so you can get by on fewer calories, and increasing hunger so you can take full advantage of any food that you find. Even though you’re deliberately trying to lose weight to improve your looks and health, your body looks at the calorie reduction as a sign of impending starvation and adjusts accordingly.
So unless you understand what’s happens when you cut back on your calories, and make the appropriate adjustments, including taking the right supplements, you can reach a plateau fast.
Put all this together and it's no wonder that most people find it impossible to lose any significant amount of fat, to keep any fat they do lose from coming back on, and to prevent loss of muscle while they’re dieting.
Effective Fat Loss
In my mind the most important steps to effective fat loss, besides reducing calories and exercise, are:
- Increasing fat release from the fat stores in the body, including cellulite - this is done by triggering lipolysis via various mechanisms including triggering the right signaling systems (for example by selectively increasing cyclic AMP levels in fat cells either directly or indirectly) and maintaining thyroid hormone levels and activity.
- Decreasing fat formation or lipogenesis. This is done by using various ingredients that decrease the stimulus and the enzymes that support lipogenesis. Decreasing inflammation, insulin resistance and cortisol secretion are important in both increasing fat release and decreasing fat formation.
- Increasing the elimination of the released fat from the body by burning it up and by flushing it out. Increasing the burning of fatty acids is done by increasing the metabolic rate (including normalizing thyroid hormone levels, increasing T3 formation and effect, and increasing UCP3 uncoupling protein – these also increase lipolysis), increasing the transport of fatty acids into the mitochondria (the fat furnaces of the body) and by priming and optimizing the functioning of the TCA cycle so that beta oxidation and the efficient utilization of the basic 2 carbon groups that result from fatty acids metabolism. Increasing the removal of fat from the body is done by increasing the amount of fatty acids that are dumped into the urine and flushed out of the body.
- Targeting fat loss and not muscle loss. This is done by increasing levels of certain hormones and factors, such as IGF-I that have anti-catabolic effects.
- And counteracting the metabolic effects of dieting, i.e. increased hunger and decreased metabolic rate.
And that’s what LipoFlush is all about. LipoFlush does it all and then some because it attacks the problem of getting rid of body fat in innovative ways.
LipoFlush not only has all the “usual suspects” - the fat loss ingredients that are in all the other high profile weight and fat loss supplements, but it also has ingredients, and synergistic combinations of ingredients not found anywhere else.
The natural ingredients in my supplements work synergistically at many sites to produce the desired fat loss effect, without side effects and with health benefits to boot. Targeting various ingredients to affect various aspects of pathways that lead to specific effects, as against violently disrupting a specific pathway as some drugs do, is a much more natural and effective way to go.
LipoFlush - The Nutritional Equivalent to Liposuction
What better way to lose body fat than to simply make it disappear? This is the promise of liposuction and in fact it does deliver somewhat as liposuction is one of the most effective ways to decrease body fat. But it has some serious problems to overcome before it becomes everyone’s favorite way to lose body fat.
The good thing about liposuction is that it basically takes fat out of the metabolic equation. You don't have to worry about the calories in that fat since it's physically removed. Up to now any other method of losing body fat has involved increasing the calorie deficit by either exercising or dieting, and usually both, so that the fat is burned as fuel to make up the calorie deficit.
But liposuction has its problems. First of all liposuction is a surgical procedure and like all surgery, it carries inherent morbidity and mortality risks – you can get sick and even die from the surgical procedure alone. Also liposuction is best used for small problem areas. In fact it doesn't do that good a job on large areas since it can leave the areas looking lumpy and uneven. And doing large areas carries much more risk. And last of all liposuction doesn’t just suck out your body fat, it can also suck your wallet dry.
Wouldn't' it be much nicer if you could just take the fat out of the equation, the same way that liposuction does, but do it naturally? And wouldn’t it also be nice if you could take the fat off in the problem areas and everywhere else at the same time, and not have to mortgage your house to do it?
Well now you can. Not only does LipoFlush help you to burn off the fat more efficiently, it also flushes some of your fat out of your body and takes that fat, just like liposuction does, out of the metabolic equation. Like liposuction, LipoFlush contains a number of ingredient combinations including the Choline and Carnitine and CLA and Guarana Combos that can make some of your fat simply disappear.
But unlike liposuction, LipoFlush can do it in the problem areas and also evenly all over your body, leaving you with an aesthetic looking body with just the right look. And it’s affordable. In fact, given the high cost of the ingredients in LipoFlush, never mind the work that’s gone behind this innovative product, it’s a real bargain.
History of LipoFlush
I’ve been involved in the sports and weight loss business for four decades. For most of that time I’ve helped athletes in all sports, from professional bodybuilders to Olympic 100 meter gold medallists, optimize their body weight for maximum performance. I also operated a bariatric clinic for over two decades, seeing and helping many thousands of overweight people lose weight and body fat.
As well I’ve researched and written books and hundreds of magazine articles (in top fitness, sports and bodybuilding magazines) about ways to optimize body composition for over three decades.
All this time I’ve been searching for the ideal weight loss supplement. One that wasn’t all smoke and mirrors, as are many of the weight loss supplements on the market today, regardless of price, but really worked, and was safe. In fact, not only safe but a supplement that naturally increased health and well being, as well as helping people to reach their weight and body composition goals.
All of my knowledge and research has finally come to fruition in LipoFlush, the first of a new generation of supplements incorporating the latest in fat loss knowledge and technology.
This amazing, patent-pending formula produces an entirely new level of effectiveness never before seen in the diet supplement industry. In fact, it is the first product ever to look at all aspects of weight loss and contains dozens of ingredients that work synergistically to maximize fat loss. The ingredients in this evidence-based, research-driven formula have been proven to affect your metabolism and result in unprecedented fat loss, without the use of ephedra, and without causing any negative health effects.
LipoFlush is the culmination of my four decades of research and involvement in the sports and weight/fat loss fields. LipoFlush is a true fat loss breakthrough that is unequaled in its ability to attack fat metabolism at several levels and bring the fastest possible fat-loss and muscle-sparing results.
It’s so good that LipoFlush is used by many of the top natural bodybuilders and other amateur and professional athletes to optimize body composition and performance. With LipoFlush they’re able to maximize muscle mass while taking body fat levels to the absolute minimum for their needs. They’re finding that LipoFlush is the perfect supplement to complement their diet and training efforts. And with the emphasis on drug testing in many of these sports, LipoFlush offers the advantages of some of the more potent fat loss and anti-catabolic drugs, without any of the side effects.
The combinations of choline and carnitine, guarana and CLA, HCA, carnitine and fumarate, and yerba mate, also combined with guarana, are but four examples of the interactive science behind LipoFlush.
Version III of LipoFlush represents the third evolution of this supplement. Each formulation is an improvement over the previous one, taking into consideration the most recent research and findings, and applying these to make LipoFlush even more effective.
And it’s not just what’s in LipoFlush that’s important, it’s what’s not in it as well. In looking at the possible list of ingredients, I eliminated those that I felt were useless, but that are the backbone of many of the weight loss supplements.
One of these ingredients is chitosan. Several studies and reviews have concluded that it’s useless for weight loss. For example, a recent study looked at the effectiveness of chitosan as a weight loss product, based on the exaggerated claims that it traps dietary fat before it’s absorbed into the body and thus takes hundreds of calories out of the equation.
The study found that chitosan, in the dosages present in these formulations, was far from being a fat trapper and only accounted for one gram of fat per day – that’s a whooping 9 calories a day taken out of the equation. The authors of the study concluded that “The fat trapping claims associated with chitosan are unsubstantiated.” I concluded that it wasn’t worth including chitosan in the LipoFlush formulation.
Ditto for the so called carbohydrate blockers such as phaseolus vulgaris extracts since any appreciable carb blocking effects that results from high doses is tied in with decreased absorption of protein, peptides and amino acids. As well, animal studies have shown that ingestion of phaseolus vulgaris may result in injury to the gastrointestinal tract.
LipoFlush Version III
Version III of LipoFlush represents the ongoing improvement of the best fat and weight loss supplement on the North American and International markets. LipoFlush III represents a new paradigm and is a quantum leap above all other products that target weight loss and body composition.
The previous version of LipoFlush already represented the ultimate fat and weight loss product, especially for those that exercise. However, the new version is a dramatic improvement on a product that already had no competitors.
In keeping with the holistic, multifunctional approach that LipoFlush takes to weight and fat loss and improving body composition, over a dozen ingredients have been added that enhance various pathways involved in these processes such as increasing fat breakdown and utilization, decreasing appetite, increasing satiety, maintaining muscle, etc.
For example damiana was added to make up a guarana, yerba mate combo that has been shown to enhance weight loss (see below).
Hoodia extract, from the Hoodia cactus found in parts of South Africa, was added to work synergistically with other ingredients, such as calcium, HCA, citrus aurantium, garcinia, andsomeneurotransmitter precursors (such as DMAE, tyrosine, mucuna pruriens andcholine), to decrease appetite, and acanthopanax senticosus to help decrease body fat.
Banaba leaf extract increases insulin sensitivity as well as promoting weight loss. The active ingredient in banaba extract, corosolic acid,has been shown to have some anti-obesity potential. Cinnamon has also been shown to affect insulin metabolism and increase insulin sensitivity.
Vitamin D3and magnesium were added to increase the anti-obesity effects of calcium. As well, vitamin D3, based on its anti-inflammatory and immune system effects has been shown to enhance health beyond just helping to build strong bones (see below).
Zincwas added since it’s been shown that there is an improvement in insulin resistance with zinc supplementation and that zinc is involved in controlling some of the aspects of obesity. Zinc also improves calcium metabolism and thus the beneficial effects that calcium has on fat metabolism (see below).
Pro-Inflammatory Cytokines, Insulin Resistance and Cortisol
One of the biggest changes in LipoFlush III is the emphasis on the pro-inflammatory cytokines, a subject that is increasingly preoccupying researchers to the point that today they’re one of the hottest research topics. Pro-inflammatory cytokines (markers and regulators of inflammation) have been implicated in obesity, visceral body fat (fat around the belly), a variety of diseases and in aging. As such, they’re becoming increasingly important when it comes to dealing with the human condition, including many diseases, the accumulation of body fat and quality and length of life itself.
But what’s interesting for our purposes is that these cytokines have been linked to changes in various hormones and functions in the body and can lead to increases in body fat, including abdominal fat, and decreases in muscle mass.
While the emphasis of some of the new diet pills is on cortisol and the effect it has on increasing body fat, in reality increased cortisol, especially local increases in body fat, is simply another manifestation of a system gone wrong, as evidenced by the increase in the pro-inflammatory cytokines seen in obesity, rather than the cause. In fact increases in cortisol, insulin resistance, and a host of other maladaptive responses, often find their origins and manifestations in the increase in the pro-inflammatory cytokines.
Because this concept is so new and revolutionary, I cover it in much more detail later on (see Is Obesity an Inflammatory Condition?). For now it’s important to realize that LipoFlush is formulated to help us decrease the counter productive effects of the pro-inflammatory cytokines not only on body fat and skeletal muscle, but also on our health and longevity.
There are many ingredients in LipoFlush that target inflammation and in particular the pro-inflammatory cytokines including L-carnitine, phosphatidylserine, vitamins B6, B12, folic acid and D3, betaine, calcium, magnesium, curcumin, willow bark, quercetin, ginger, yerba mate, green tea extract, alpha lipoic acid, capsicum, kelp and various antioxidants.
L-carnitine(LCAR) is considered by many to be essential nutrient with critical roles in energy metabolism. Several studies have shown that LCAR decreases the production of some of the pro-inflammatory cytokines and has anti-inflammatory and immunomodulating effects. In a recent study the authors concluded that the use of L-carnitine can improve cellular defense against chronic inflammation and oxidative stress, most likely by modulating the specific signal transduction cascade activated by an overproduction of pro-inflammatory cytokines and oxidative stress.
Vitamin Ddeficiency is fairly common, especially in the more Northern climates. Several studies have found a link between vitamin D deficiency and various disorders that have an inflammatory link, including obesity, coronary artery disease, diabetes and the metabolic syndrome (see below). As well, studies have shown an association between vitamin D deficiency and inflammation in otherwise healthy people, and a decrease in inflammation with vitamin D supplementation.
Curcumin, which comes from the spice turmeric, is documented to have anti-inflammatory and antioxidative benefits. As an antioxidant, curcumin reduces the activity of certain enzymes, inhibiting all branches of the arachidonic acid cascade, and reduces pro-inflammatory cytokine synthesis. The rhizome of this plant has been traditionally used as an anti-inflammatory agent in Ayurvedic medicine. In a double-blinded trial, post surgical patients receiving curcumin experienced reductions in stiffness and joint swelling comparable to the effects of phenylbutazone, a potent anti-inflammatory drug.
Of all the spices and herbal preparations it seems that only the spice turmeric has any anti-inflammatory effects. This was the conclusion of a study of a variety of Ayurvedic and herbal preparations, which was presented recently at the 9th Asia Pacific League of Associations for Rheumatology Congress. In this study, a variety of herbal and Ayurvedic preparations were tested in rats. The rats were fed oral doses of the varied herbal and Ayurvedic recipes. Only turmeric showed anti-inflammatory effects when tested on irritated paws of the rats.
Green tea also has significant health and anti-inflammatory properties. Green tea extract may well prove to be more useful than green tea itself. A recent study found that green tea extract supplements retain the beneficial effects of green and black tea and allow larger doses of tea polyphenols to be used without the side effects of caffeine associated with green and black tea beverages.
The bioflavonoid quercetin has been shown to have significant anti-inflammatory activity in cases of both acute and chronic inflammation and protective effects against the pro-inflammatory cytokines. As well, several inflammation-promoting pathways are known to be inhibited by quercetin. For example quercetin is known to have antioxidative and antihistaminic effects.
As well, LipoFlush contains ingredients to decrease inappropriate increases in cortisol and thus augment the decrease in the pro-inflammatory cytokines. These ingredients decrease the factors responsible for both excess body fat and increased cortisol.
For example phosphatidylserine has been shown to not only to reduce levels of inflammatory mediators, but also to dampen the ACTH and cortisol response to physical stress and decrease the reaction of the body to stressors.
Beta sitosterol, used mainly for people with prostate problems,also has immune system, cortisol controlling and anti-inflammatory effects. In one study a mixture of beta sitosterols were tested on marathon runners. The supplemented group, but not the placebo group, showed increased immune cell numbers, decreased inflammation, and decreased cortisol levels.
Alpha lipoic acid(ALA), an essential cofactor of mitochondrial respiratory enzymes, is also a potent antioxidant that can recycle other antioxidants such as vitamin C, vitamin E and glutathione. ALA was added to LipoFlush III to increase insulin functioning and sensitivity and decrease body fat by its actions on the pro-inflammatory cytokines and on secondary cortisol elevations. Interestingly enough a combination of ALA and CLA, also in LipoFlush, had a synergistic effect on increasing insulin sensitivity.
But there is more to ALA than its antioxidant and anti-inflammatory effects as ALA is also. ALA has recently been shown to have significant anti-obesity effects. A recent study found that ALA decreases hypothalamic AMPK activity and causes profound weight loss in rodents by reducing food intake and enhancing energy expenditure.
Besides the ground breaking effects that LipoFlush has on the pro-inflammatory cytokines, and on insulin sensitivity and body fat cortisol production, it has a host of other ingredients that together make LipoFlush the premier fat loss supplement.
1. Choline and Carnitine – the Dynamic Duo for Fat Loss
Choline and carnitine are commonly used nutritional supplements, usually used alone or in combination and usually for the purposes of fat loss. Carnitine is essential for fatty acid transport and proper muscle function, and some studies have shown that carnitine supplementation improves exercise performance. Choline is a lipotropic agent that prevents deposition of fat in the liver. It is an essential nutrient for humans by giving cell membranes structural strength and providing structure to cell membranes and is involved in the signaling across this membrane as well as synthesis and release of the neurotransmitter acetylcholine. Like carnitine, choline supplementation may also improve physical performance.
Choline is the major source of methyl-groups in the diet (one of choline’s metabolites, betaine, participates in the methylation of homocysteine to form methionine).
The possible synergistic interaction between carnitine and choline has been known for several years. A study on rats published a few years ago clearly showed that choline in combination with caffeine plus carnitine resulted in a significant conservation of carnitine and augmented exercise performance and promoted fatty acid oxidation as well as disposal in urine.
As well, the use of the three supplements resulted in two other beneficial effects, a decrease in blood triglycerides and an increase in the triglyceride content of skeletal muscles. Since muscle fat is used to supply energy to exercising muscles, and actually increases muscle size, much like glycogen, this is a whole different thing to increasing fat in subcutaneous skin and other fatty areas of the body. The increase in intramuscular fat also helps endurance and recovery and would be useful on any diet.
But there’s more to the story. A recent study has shown that choline and carnitine supplementation with or without exercise alters carnitine status, body fat and biochemical markers of fat oxidation in humans. In this study nineteen women were placedin three groups: 1) placebo, 2) and 3) choline or carnitine preloadingperiod of 1 wk followed by supplementation with choline pluscarnitine during wk 2-wk 3.
There were several interesting results of this study outlining the effects of choline, and choline plus carnitine supplementation. Without going into all the details the study showed that the choline-induced decreasein serum and urinary carnitine is buffered by carnitine preloading,and these supplements shift tissue partitioning of carnitinethat favors fat mobilization, incomplete oxidation of fattyacids and disposal of their carbons in urine as acylcarnitinesin humans.
Flushingout fat in the urine has another interesting and useful effect for those trying to lose body fat. Flushing out fat in the form of acylcarnitines acts as an osmotic diuretic and increases urine flow, in some people more than others. LipoFlush seems to have much more of a diuretic effect on people who are retaining fluid in the first place. It does not affect the serum electrolytes (I’ve checked serum levels of several electrolytes and minerals and found not change in the sodium levels, but improved levels of potassium, calcium and magnesium) does not dehydrate the body.
As such, LipoFlush, along with its effects on appetite and fat loss, may be effective in decreasing fluid retention, a problem often seen in people dieting. As well, LipoFlush is the ideal cutting or definition supplement for bodybuilders or anyone who wants to minimize bodyfat and not have their definition blurred by water retention.
For women there may also be an added benefit in that LipoFlush may be useful in relieving the symptoms of PMS. That’s because fluid retention can worsen the symptoms of the premenstrual syndrome (PMS). Women with severe symptoms may experience increased irritability and decreased ability to cope with everyday stresses during the premenstrual phase - they often compensate by eating more. In these women the weight gain is due to a combination of fluid retention and increased caloric intake.
You can minimize fluid retention by cutting down on salt intake - avoiding foods heavy in salt and use of the salt shaker, and in the more severe cases using medication such as prescription diuretics. However, LipoFlush, because of its diuretic like action, may naturally decrease fluid retention and improve symptoms.
The diuretic effect of LipoFlush is also easily controlled since it is dependent to some extent on fluid intake. Taking in more water (keep away from diet pops and other drinks that have salt in them) increases this diuretic effect while curtailing water intake decreases it.
The bottom line is that choline and carnitine supplementation increased fat loss by both increasing the breakdown and burning of body fat and, interestingly enough, actually flushing fat (in the form of acylcarnitines, which are actually chunks of fatty acids combined with carnitine) into the urine and out of the body. In this latter action it’s as close as you can get to being the nutritional supplement equivalent of liposuction. LipoFlush will literally flush the fat right out of your body.
2. Conjugated Linoleic Acid (CLA) and Guarana Combo
This combo has been shown to not only decrease the size of fat cells but also to decrease cell number.
Both CLA and guarana have been shown to increase weight and fat loss and improve body composition. For example, studies in mice fed CLA showed a marked reduction in body fat and an increase in body protein levels. Other animal studies demonstrated similar or even better results.
But CLA has marked effects in humans as well. A study published in the International Journal of Obesity found that those who were given CLA for a four week period had significant decreases in abdominal fat. As well, a recent study concluded that long term CLA supplementation not only helps to decrease body fat but also helps to maintain weight loss in the long term.
Even more revealing, however, is the synergism shown by the combination of guarana (from a plant found in the Amazon and used for its effects on decreasing appetite and increasing weight loss) and CLA. While studies have shown that CLA can reduce the volume of fat cells, in one study two groups of mice given CLA or CLA plus guarana had a significant reduction in fat mass. However, the group of mice that were fed the CLA/guarana combination not only showed a decrease in the size of the fat cells but also a decrease in the number of fat cells (FASEB Journal, v. 16, no. 5, pt. I; March 22, 2002).
Because of its effect on decreasing the number of fat cells, this combo contributes to the body shaping effects of ThermoCell 35.
3. Chromium and CLA
Chromiumenhances insulin sensitivity and decreases insulin resistance, and helps you to lose body fat.
One of the most frustrating aspects of being overfat is that your body has become conditioned to converting excess calories, especially in high carbohydrate intake, into body fat. Part of the problem with this fat conditioning involves insulin. The problem is that as you gain more body fat you become more insulin resistance so that you need more insulin to do the same job as when you had less body fat. This increase in insulin decreases your ability to use body fat as fuel, and stores more energy as body fat. The end result is a fatter you.
Chromium helps to increase insulin sensitivity and thus your body’s ability to burn off body fat as a preferred fuel, and decreases body fat production.
Although most diets just barely provide the RDA for chromium, for many it’s not enough to make up for daily losses, especially if they exercise. With LipoFlush you get another 50 mcg per day (using two doses daily), so that you have all the chromium you need for fat loss purposes.
But not any kind of chromium is OK. For example the most commonly used form of chromium, chromium picolinate, has potential adverse effects associated with its use. The amino acid chelate form of chromium used in LipoFlush is a readily absorbable and biologically active form of chromium that enhances insulin sensitivity, without side effects.
It’s been shown that combining chromium with CLA enhances insulin sensitivity and body composition even more when used together. A recent study found that CLA alone lowered body weight, total body fat mass, and visceral fat mass, the last of which decreased further with the combination of CLA and Chromium.
4. Hydroxycitrate (HCA), Carnitine and Fumarate
Laboratory research suggests that garcinia cambogia extract or HCA may be an effective compound for promoting weight loss. It is believed that HCA acts in several different ways. It is an effective appetite suppressant, and also limits the production of cholesterol and fatty acids in the body. It is also believed to raise body temperature to act in a thermogenic manner. HCA has also recently been shown to suppress weight regain.
HCA is not one of the new kids on the block. Over the last 30 years there has also been a lot of research on HCA and its effects on fat metabolism, with even the early research looking at its effects on fat metabolism.
Theoretically, because HCA decreases the 2-carbon pool necessary for the formation of fat, and increases certain enzymes that promote fat oxidation, it should increase fat oxidation and decrease fat formation. In fact, several studies have shown that these effects do occur. For example, in one study, HCA and other tricarboxylic acids were shown to inhibit fatty acid synthesis from body glycogen without affecting protein synthesis.Studies have also shown that HCA has appetite suppressant effects, especially if taken prior to meals.
Even though its use in weight loss is supported by animal studies, where it appears to act (by a mechanism which is not yet clear, although some studies have implicated a serotonin connection) by reducing food intake, much of the research on the effects of HCA on appetite and body composition has been inconclusive and in some cases showed no effects, especially in humans. As well, there’s been a lack of studies that show significant long lasting effects on weight loss and totalfat formation and oxidation.
Over the past few years, however, this situation has changed. A recent study on humans has shown that 2 weeks of taking as little as 300 mg of HCA three times a day reduced 24 hour energy intake in obese humans with no increase in hunger.
Another recent study has shown that HCA has sustained long-term effects in rats on various parameters of weight loss and hunger. An interesting finding in this study is that the fat content of the diet seemed to be important for the long-term suppressive effect of HCA on feeding. HCA had little effect on rats that were on a very low fat diet.
The bottom line is that HCA has the potential to decrease appetite and weight and fat loss and, along with a proper diet, exercise and other targeted nutritional supplements, should be part of any serious weight and fat loss regimen.
But there’s more!
A recent pilot study showed that the use of hydroxycitrate (HCA), carnitine and pyruvate to obese subjects resulted in a remarkable rate of body-fat loss and thermogenesis, which pointed to an uncoupling of fatty-acid oxidation – that is the energy from the burning of fat was thrown off mostly as heat, and thus took some fat out of the metabolic equation.
In LipoFlush I’ve combined HCA with carnitine fumarate. I believe that fumarate has an advantage over pyruvate in that it is a more direct Tricarboxlyic Acid cycle (TCA cycle) intermediate resulting in an anapleurotic increase in TCA cycle intermediates and an increased TCA cycle flux.
The increased flux, combined with the activation of fatty acid oxidation induced by HCA and carnitine, increases fat breakdown and the oxidation of fatty acids, along with an increase in uncoupling protein. The overall result is an increase in fat breakdown and an increase in heat production from the metabolism of fat.
5. Yerba Mate, Damiana, Guarana Combo
Researchers in Switzerland performed a study on human subjects (in 1999) that indicated yerba maté could be beneficial as a weight-loss aid. They noticed a thermogenic effect in healthy individuals where a drop in respiratory quotient was observed—indicating a rise in the proportion of fat oxidized.
In another study, yerba maté was given in combination with the plants guaraná and damiana (all three are in LipoFlush). This combination prolonged gastric emptying (which made the subjects feel “fuller” longer) and significantly reduced body weight in overweight people over a 45 day period.
Clinical studies indicate yerba maté leaf inhibits lipoxygenase, an enzyme involved in inflammation and inflammatory diseases. Yerba maté extracts also have been shown to relax smooth muscle, act as a choleretic (increase bile flow), and inhibit vasoconstriction.
A recent (2002) U.S. patent cites yerba maté for inhibiting monoamine oxidase (MAO) activity by 40–50% in vitro, reporting that it might be useful for a variety of such disorders as “depression, disorders of attention and focus, mood and emotional disorders, Parkinson’s disease, extrapyramidal disorders, hypertension, substance abuse, eating disorders, withdrawal syndromes and the cessation of smoking.”
Yerba maté has significant antioxidant activity, demonstrated in numerous studies. Its high antioxidant values are linked to rapid absorption of known antioxidant phytochemicals found in maté leaves. An infusion (tea) of the leaf has been demonstrated to inhibit lipid peroxidation—particularly LDL (low-density lipoprotein) oxidation. Oxidation of LDL is considered to be the initiating factor in the pathogenesis of atherosclerosis.
Another study in vitro has shown yerba maté to inhibit the formation of advanced glycation end products (AGEs), with an effect comparable to that of two pharmaceutical AGE inhibitor drugs. The formation of AGEs play a part in the development of diabetic complications.
6. Guggulsterone and Phosphate Combo - Support for the Metabolism and Thyroid
As we mentioned above, your body reacts to decreasing calorie intake, and what it believes is impending starvation, by putting in place three main survival mechanisms.
Number one it decreases your metabolic rate, mainly by decreasing the amount and activity of thyroid hormone, and number two it increases your appetite and cravings so that anything that’s even remotely edible is gobbled up. The third mechanism is by decreasing the action of neurotransmitters in the brain, with the purpose of decreasing energy output and metabolism.
Unfortunately your body by putting itself in survivor mode counteracts and even sabotages your weight loss efforts.
Various ingredients in LipoFlush are meant to counteract all three of these mechanisms. We’ve already mentioned several ingredients that decrease appetite and we’ll mention more below.
Several ingredients in LipoFlush optimize and increase thyroid hormone activity and increase metabolic rate. For example, phosphates, guggulsterones Z and E, and kelp, promote thyroid function, increase the metabolic rate and support thermogenesis. All actions that promote fat breakdown and oxidation.
Studies have shown guggulsterones to have thyroid stimulating activity, and increases thyroid efficiency by increasing the conversion of the less active T-4 to the more active T-3. The use of guggulsterones has been shown to result in a decrease in body fat, and to also lower cholesterol levels.
LipoFlush also contains substantial amounts of natural phosphates, in the form of calcium and potassium phosphates, which have also been shown to prevent a decrease in T-3 and increase the BMR.
And there’s more good news. The combination of guggulsterones and phosphates has been recently shown to optimize body composition in adults.
7. Neurotransmitter Precursors
As mentioned above, dieting tends to decrease neurotransmitter levels in the central nervous system resulting in lowered metabolic rate, decreased activity, hunger and fatigue.
LipoFlush counters this by providing tyrosine, DMAE, mucuna pruriens, and various choline compounds including choline and lecithin, ingredients that increase neurotransmitter function and increase energy, activity and well being as well as decreasing appetite. Tyrosine, an amino acid, is also a precursor for thyroid hormone. As well, choline and inositol act as lipotropic agents and help optimize fat metabolism.
Several of the ingredients in LipoFlush, including mucuna pruriens, glycine, tyrosine, zinc, and some of the other ingredients that decrease inflammation, optimize growth hormone secretion and activate the protein sparing, lipid burning effects that growth hormone has.
8. Methylcobalamin (Vitamin B12), Vitamin B6, Betaine and Folic Acid, for Increased Health and Energy
LipoFlush contains high doses of Folic acid, Vitamin B6 and methylcobalamin, the biologically active form of B12 (not the cyanocobalamin, the synthetic and not as metabolically active form of B12 that is generally used), increases energy and health.
There is so much to say about the effects that this trio has on metabolism, macronutrient metabolism, energy systems, and on combating the adverse effects of pollution and mercury toxicity, that it would take a separate book to document it all.
Suffice it to say that the health effects of all three of these B vitamins have been extensively documented. And that several of the medical parameters, such as homocysteine, cholesterol and C - reactive protein, markers of heart disease and inflammation in the body, are decreased by the use of hefty doses of these vitamins, and by some of the other ingredients in LipoFlush, including betaine (trimethylglycine – three methyl groups attached to the amino acid glycine).
Besides acting as a precursor for methionine, choline and carnitine, betaine has other useful properties. Betaine has been shown to protect tissues under stress, regulate fatty acid metabolism, reduce body fat in animals, and be useful in the prevention of chronic diseases. Betaine also acts as an important methyl donor.
Methyl donors are important for the methylation reaction, which adds a methyl group (one carbon atom and three hydrogen atoms), on proteins, enzymes, chemicals, DNA, and amino acids like homocysteine. Methylation is important for maintaining many functions in the body including genetic expression, and neurological and musculoskeletal function.
LipoFlush contains a number of ingredients involved in methylation, including vitamin B12 (as methylcobalamin – the biologically active form of B12 that has an added methyl group – the synthetic B12, cyanocobalamin, a much cheaper form of B12 with a cyanide molecule, has to be metabolized to methylcobalamin in the body), folic acid, B6, betaine, choline and lecithin. These ingredients optimize macronutrient metabolism and help maximize muscle mass and decrease body fat, often acting synergistically to achieve their effects.. As well, they decrease serum levels of homocysteine, cholesterol and C-Reactive proteins, markers and mediators of heart disease and inflammation in the body.
9. Calcium, Magnesium, Vitamin D
Calcium, while generally considered a key element for maintaining bone density and strength, also has other health benefits including reducing blood pressure, and more importantly for both men and women losing weight, the prevention of any adverse effects of dieting on bone mass and a preventative effect on osteoporosis.
For example, calcium can also help lower your cholesterol. In a recent study it was found that people with cholesterol levels in the high range of 240 to 260 reduced their total cholesterol by 6 percent when they took in an extra 1,800 milligrams of calcium a day. And the best part is that LDL (low-density lipoprotein) cholesterol--the bad cholesterol that’s implicated in coronary artery disease, dropped by 11 percent. As well, calcium has recently been inversely associated with the incidence of colorectal adenomas.
But there’s more. Calcium has also been shown to modulate the inflammatory response and to increase weight loss. A recent study found that an increase in dietary calcium intake, together with a normal protein intake, increased fecal fat and energy excretion by about 350 calories per day. This observation may help explain why a high-calcium diet produces weight loss, and it suggests that an interaction with dietary protein level may be important.
Several studies have shown that calcium plays a key role in body weight regulation and especially on fat metabolism (with possible effects on lipolysis, fat oxidation, lipogenesis, energy expenditure and appetite suppression) and thus is a useful supplement for those looking to decrease weight and body fat.
For example, Zemel et al. (2002) ;looked at the effects of calcium supplements on obese adults who were dieting. They found that a high-calcium diet (1200-1300 mg/day) resulted in greater weight and fat loss in humans compared to a low-calcium diet (400-500 mg/day).
Another study published in November, 2004 found that a high intake of calcium may hinder weight and fat regain. The study found that after putting mice on a low calorie diet and producing weight and body fat loss, that those on a low calcium diet regained their weight after 6 weeks. However, for those on a high calcium diet it was a different story. They found that the high calcium diets produced significant increases in lipolysis, decreases in fatty acid synthase expression and activity, and reduced fat regain. They also found that increasing calcium through the use of dairy products had significantly greater effects on fat regain.
The bottom line is that increasing calcium intake is a boon to those who want to not only lose weight, but to lose fat, improve body composition, and keep that fat and weight from coming back.
Magnesium, besides complementing the effects of calcium on obesity and other functions, also has important effects on its own. Low levels of magnesium promote inflammation and impact on the body’s ability to handle stress. These functions are useful in alleviating the release of pro-inflammatory cytokines, and decreasing both insulin resistance and inappropriate cortisol secretion.
Vitamin Dis important for augmenting calcium dynamics. However, it also has other important effects, for example on insulin resistance, inflammation and obesity (for more on this see below). Although getting adequate amounts of vitamin D is crucial to health, vitamin D deficiency is relatively common. As such, supplementing with vitamin D is important to realize all the benefits that it has to offer.
While the ingredients we’ve already mentioned far outclass any weight loss supplement on the market today, both in the science behind the product and effectiveness, LipoFlush has many other ingredients that act to further increase fat breakdown and oxidation, increase metabolic rate and thermogenesis, decrease appetite and provide you with nutrients that increase energy, well being and health. We’ll look at some of these below.
Cordyceps sinensisis a highly valued medicinal mushroom that helps increase stamina, energy levels, and endurance, and by these actions leads to increased fat loss.
Citrus aurantiumis widely used for stimulating the breakdown of fat, by causing the release of noradrenaline (a stress hormone) at beta-3 receptor sites creating chemical reactions that increase fat breakdown. Beta-3 receptors in the body increase the rate at which fat is released from the body stores (lipolysis) and increase resting metabolic rate (thermogenesis) Physical activity will increase this thermogenic effect and further enhance the thermogenic effect of Citrus Aurantium towards healthy and permanent weight and fat loss.
Extracts from citrus aurantium contain a rare combination of five adrenergic amines: synephrine, N-methyltyramine, hordenine, octopamine, and tyramine. These amines stimulate beta-3 cell receptors with minimal effect on other alpha and beta-receptors. This could indicate that citrus aurantium increases metabolic rate without affecting heart rate or blood pressure.
Stimulation of these beta-3 receptors elicits the breakdown of fat. Simultaneously, this stimulation causes an increase in the metabolic rate – thermogenesis – that burns calories. Citrus aurantium may also act as an appetite suppressant.
Biotin, one of the twelve B vitamin, increases the metabolism of carbs and fats.
Magnesium (oxide andoctadecanoate) increases fat metabolism in rat liver and may have a similar effect in humans.
Caffeine, kola nut, ginseng, theobroma cocoa complex and green teaincrease energy and thermogenesis, decrease appetite and increase fat oxidation. For example, green tea has been found to elevate energy expenditure in humans. Recently a study found that cocoa has a modulating effect on fat metabolism and increases thermogenesis.
Potassium helps correct the potassium loss often seen with dieting. Loss of potassium can lead to fatigue and lethargy, which can be counterproductive to dieting.
Celluloseand cellulose gum act to decrease appetite and decrease fat absorption. Also, unlike soluble fibers, these insoluble fibers do not increase short chain fatty acids formation and absorption from the bowels.
Several of the ingredients in LipoFlush, such as cayenne, Hawthorneberry, ginger root, and quercetin, are either thermogenic and/or supportive to weight loss either directly, or indirectly by providing certain health benefits.
Grape seed extract, green tea, andquercetin are potent antioxidants and help decrease the effects of restrictive diets on oxidant stress and on antioxidant status.
CLA, magnesium, zinc, green tea, alpha lipoic acidand biotin increase insulin sensitivity and thus decrease lipogenesis and increase fat breakdown.
Bioperine, a patented preparation of the black pepper thermogen, piperine, has demonstrated the ability to improve the absorption of nutrients. This result in less degradation of the active compounds; thereby ensuring higher percentages get through to work their magic!
Glycinehas been shown to protect against increased circulating nonesterified fatty acids (NEFA), fat cell size and intra-abdominal fat accumulation.
Where’s the Proof?
Over the past three years I’ve conducted several clinical studies and have had feedback from hundreds of people who have used LipoFlush.
In one study I compared two 24 hour periods, one with LipoFlush and one without, in which I obtained minute by minute energy expenditure values on one woman. Physical activity and diet were almost exactly the same.
In a previous study, the test subject burned 2041.78 kcals/d without LipoFlush and 2279.27 kcals/d with LF. The difference at that time was 237.5 or 11.6%. The dose used was 2 tablets taken in the AM with her normal breakfast. The increase in metabolism lasted for close to 10 hours on the one morning dose. It also dramatically reduced her appetite. The data for this study is available at www.MetabolicDiet.com.
The follow-up to this study, using 2 tablets of LipoFlush twice a day showed a phenomenal 23.8% increase in the calories burned over the control state.
Other less formal clinical studies done on several groups of people found the same response to LipoFlush. In the first group that tried LipoFlush I didn’t have them change their lifestyle, training or even their diet. All they did is use 4 tabs of LipoFlush twice a day.
The results were extremely interesting. All six lost weight, mostly body fat, without changing what they were doing except taking the LipoFlush. One chap, lost 25 lbs in four weeks but on questioning him further I found that he cheated. He felt the LipoFlush working, liked the way he felt, and wanted to help the process along. So he trained harder and put himself on my Radical Diet, an extreme very low calorie version of my Metabolic Diet.
The other five lost anywhere from 6 to 16 lbs in the four weeks without appreciably changing what they did. Needless to say they were really pleased with the results. There was one bias in this group of six people in that they were really charged up about going on the LipoFlush and expected great things from it. As such, it’s difficult to remove the placebo effect from this group and they might have lost significant amounts of weight even without the LipoFlush. Ideally I would have had two groups who were nearly identical in everything except that one group would take the LipoFlush and the other pills that looked like LipoFlush but without any active ingredients.
The second group of people were slightly different and put on a protocol that was more hands on. All six were already training and were in a steady state, no change in body composition for at least a month prior to going on the LipoFlush. In this group I increased their training load and made some changes in the macronutrient content of their diet. I had them follow the Metabolic Diet at a slightly reduced calorie intake than what they were on before taking the LipoFlush. The 4 week results on these six people were as follows:
They showed an average of just over one pound of fat loss every three days for the full four weeks, with the total fat loss averaging out at 10 lbs. These changes were arrived at this through the use of body fat measurements and total body weight done once a week, usually Saturday morning.
Weight loss over the four weeks was interesting. At first there was an average weight loss of almost one pound a day for the first five days. After that most of the people didn't lose much more weight. In fact the overall weight loss was less than 5 lbs, which means they gained muscle mass while at the same time losing weight.
Subjectively all six felt better, more energetic, and had better training sessions.
Now these are not dramatic weight and fat losses. But you have to keep in mind that all six of the subjects were in shape and didn't go on a strict weight loss diet, they just followed the Metabolic Diet as far as cycling their macronutrient intake with a daily calorie intake of only about 200 calories less than their diet prior to going on the LipoFlush.
Although all of this is pretty informal, it’s obvious that LipoFlush can help you lose significant amounts of body fat, even if you don’t do anything else different. And even more important, it can help you lose a lot more if you diet and exercise.
Even more impressive are the dozens of unsolicited testimonials that people have sent me. People in all walks of life, men and women, teens, boomers and the elderly, including bodybuilders and even endurance athletes, have found LipoFlush to dramatically decrease their body fat and increase their energy levels.
On the other end of the scale, several women who gained weight after having a baby but were unable to take it off no matter what they did, found that LipoFlush was able to help them get their figures back.
In the last year or so I’ve had a lot of people tell me that LipoFlush did what no other diet and nutritional supplement was able to do for them. And that’s to effectively deal with problem areas, whether it was cellulite or an expanding waist line.
Going to Waist
I’ve had a lot of women and men complain that they’re putting weight on and it’s all going to their waistline. Besides being unattractive and limiting your ability to touch, and sometimes even seeing your toes, fat around your middle is more of a health hazard than body fat any where else.
Several new studies show that increasing waist size increases the risk for developing metabolic syndrome, diabetes, heart disease, and other illnesses. In fact the size of your waist appears to be a better predictor of disease than either your weight, your BMI (your weight in relation to your height) or your waist-to-hip ratio.
Waist size is easy to measure using a tape, but most people are aware that their waist is expanding before then even think of measuring it. That’s because you can tell by how your clothes fit and how you look in the mirror without clothes on. But for a more objective view, and as a way to measure your risk, it’s a good idea to use a tape measure.
If you’re of average height and your waist size is more than 36 inches, then it’s time to do something about it. If it’s more than 40 inches then you’re already at risk. That’s because abdominal fat measured by waist circumference can indicate a strong risk for obesity, diabetes and other diseases whether or not the person is considered overweight or obese according to his BMI.
Several studies have shown a correlation between waist size and cholesterol, blood pressure, diabetes and other health risks. The most recent study looked only at men's waist sizes relative to diabetes risk. The authors of the study found that risk started to creep up when the belt size went higher than 35 inches, and that 80 percent of type 2 diabetes cases occurred in men with waists larger than 37 inches.
In a study based on data collected from 27,270 men tracked over 13 years through the Harvard Health Professionals Follow-Up Study, men who had a waist size of 40 inches or more were 12 times more likely to develop the type of diabetes in which the pancreas either doesn't make enough insulin or doesn't respond properly to insulin than men with waist sizes of 34 or less. With a waist size of 34 to 36, the diabetes risk doubled; at 36 to 38 inches, the risk tripled; and at 38 to 40 inches, the risk for the disease was five times greater.
The bottom line is that an expanding waist line, while something to avoid for aesthetic reasons, is also a significant health risk.
Spider Bite Tale
Lately a woman in her mid fifties complained to me that after being bitten by a spider she was put on a cortisone pill for the swelling. While she was on the cortisone, and especially after stopping it she complained of gaining weight, mostly around the belly, and that no matter how hard she dieted and exercised, she just couldn’t budge that belly fat.
And I've heard this story before from many others. Not about being bitten by a spider or taking cortisone-type drugs, but about a spreading waistline. The problem, as I see it, is two fold. First of all, increasing cortisol levels by taking cortisone drugs, as in the woman who was bitten by the spider, or simply secondary to inflammation, can be an instigator for obesity in general and especially abdominal obesity.
Once you gain that fat, it only takes normal levels of corticosteroids to maintain it. But you would think that at least theoretically you should be able to lose this weight and fat gain by careful dieting and exercise.
Unfortunately this is not the case with a lot of men and women because there are factors at play that may be responsible for their inability to lose weight. A lot of this is due to insulin resistance secondary to the increase in pro-inflammatory cytokines and increase in cortisol, leading to a tendency for weight gain rather than weight loss.
There is definitely a link between the pro-inflammatory cytokines and both insulin resistance and excess local glucocorticoid activity. For example, it’s been shown that an increase in pro-inflammatory cytokines results in an increase in insulin resistance, which in turn increases the formation of local cortisol production from cortisone by the enzyme 11beta-hydroxysteroid dehydrogenase.
In any case, the solution to weight gain and a spreading waistline is decrease the levels and thus effects of the pro-inflammatory cytokines, increase her insulin sensitivity, and decrease the formation of cortisol in the fat cells. LipoFlush ver III targets all of the above, plus much more.
Is Obesity an Inflammatory Condition?
We’ve already mentioned that gaining weight, especially around the middle, may be due to inflammation and the effects that inflammation has on the body. And that LipoFlush is formulated to fight this inflammation, as well as its adverse effects, especially insulin resistance and increased cortisol levels in adipose tissue.
To a lot of people this whole concept may sound far fetched. But it’s not. Who would have even imagined a few decades ago that ulcers were caused by bacteria? But they are. And today treatment involves the use of multiple antibiotics.
Because it’s not intuitive, at least at this point in our common understanding, we need to explore some of the current concepts linking inflammation and obesity.
Most of us equate inflammation with infections and injuries. Something we can see or feel. Like a boil on our skin, or a chest infection, or a swollen strained ankle. Or perhaps an ear infection in a child, with fever, aches and pains, and all the rest.
What we’re actually seeing, however, in all of these cases are the results of inflammation secondary to injury of some sort, infectious or traumatic, and thus simply the body’s response to the insult. The actual inflammatory process underlies it all and is much more than just what we see or feel.
In fact inflammation is a complex process that can be measured not only by the changes that take place with obvious infections, but also by measuring the markers in the body that uncover the fact that an inflammatory process is going on, even if the inflammation is not obvious or doesn’t result in any symptoms.
Most of us, and certainly all of us as we get older, have some evidence of chronic inflammation. In most cases, although it’s nothing we can put a finger on, there is something going on in our bodies that are making it react as if it we are going through some sort of long term, low level, infection. We can detect this inflammation by measuring certain markers of inflammation in our bodies, including pro-inflammatory cytokines such as C-reactive protein (CRP), interleukin-1-beta (IL-1 beta), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF-alpha).
Low levels of inflammation, as shown by these and other inflammatory markers are linked to various diseases and conditions, including insulin resistance, the metabolic syndrome, diabetes, coronary artery disease and arthritis. Obesity, and body fat, especially visceral adipose tissue (the fat around the belly) are both linked to low level inflammation in the body, again as measured by an increase in pro-inflammatory cytokines rather than overt signs and symptoms, and to various disease processes.
Body fat is an active endocrine tissue and is the source of several hormones and cytokines. It’s also a site of active inflammation. Surprising isn’t it to find out that a tissue that we all thought was a passive storage facility for excess calories, is actually a metabolic hotbed?
In fact, weight gain has been found to be associated with an increase in pro-inflammatory signals from adipose tissue. These signals in turn may be responsible for further increases in weight and body fat. What we have is a vicious circle where fat begets more fat, inflammation leads to insulin resistance, increase in body fat which begins the cycle again. and soon begins to affect our health.
Several studies have shown links between inflammatory markers (such as C-reactive protein) and body fat – especially visceral adipose tissue. These and others also show a link between the pro-inflammatory cytokines and both insulin resistance and excess local glucocorticoid activity. It’s been shown that an increase in pro-inflammatory cytokines results in an increase in insulin resistance, which in turn increases the formation of cortisol from cortisone by the enzyme 11beta-hydroxysteroid dehydrogenase.
While the effects may not be measured systemically (blood cortisol levels are usually normal in obese people), the pro-inflammatory cytokines have been implicated in the local regulation of cortisol, by increasing its production in fat cells. For example, it’s been shown that TNF-alpha causes insulin resistance and increased local cortisol production. And to add to the problem, it’s also been shown that body fat in obese people secretes more TNF-alpha than the equivalent amount of fat in lean people.
It’s been shown that an increase in inflammatory mediators predicts the future development of obesity and diabetes and, interestingly enough, depression. It would seem that the link between obesity and increased body fat, and increased inflammatory mediators might be considered as a cause-effect relationship. As such, decreasing levels of inflammation, and especially the pro-inflammatory cytokines may decrease body fat and weight gain by both direct, and by indirect effects. The indirect effects would be by decreasing inappropriate cortisol production and by increasing insulin sensitivity.
But there’s more to the story. Reducing the pro-inflammatory cytokines results in an increase in levels of IGF-I, resulting in an increase in fat breakdown and oxidation of fatty acids, and anti-catabolic effects on muscle mass. The overall result is an increase in fat loss while maintaining skeletal muscle mass.
As we’ve seen above, LipoFlush contains several ingredients that reduce inflammation and the production and levels of pro-inflammatory cytokines, and aid in the overall process of fat loss while at the same time decreasing muscle catabolism.
What about Cortisol
Several of the new diet supplements target cortisol. They state that high cortisol levels are to blame for increased weight and body fat, especially for abdominal fat (known in the medical community as visceral adipose tissue – VAT).
As such, the many preparations out there marketed to alleviate this condition contain a number of ingredients that are meant to decrease cortisol, with the aim of “curing” abdominal obesity and returning our abdominally fat challenged bodies to normal.
The problem is that their knee jerk reaction toward cortisol is more of a marketing point than anything else in that it assumes that it is the cortisol which is causing the increased VAT. But they’re wrong in assuming that cortisol is the main problem when it comes to gaining body fat, both overall and the fat that’s around the belly.
That’s because first of all cortisol levels are not elevated in overweight people unless they have a disease that elevates cortisol levels pathologically. And secondly decreasing cortisol overall can actually be counter productive.
We need baseline levels of cortisol to function normally. It provides a buffer for our daily stresses, and helps us to deal with inflammation, whatever the cause.
Lowering normal levels of cortisol can cause all kinds of health problems, including increasing inflammation in the body. And we know from the above discussion that increasing inflammation in the body will lead to increases in body fat and weight.
Not only that but healthy levels of cortisol actually help you to lose body fat since one of the functions of cortisol is to increase fat breakdown and use by the body.
Having said that, it’s also true that inappropriate increases in cortisol can be a problem in that it further potentiates increases in body fat. However, it’s not systemic cortisol that seems to be the problem but levels of cortisol in the fat cells themselves. That’s because fat cells contain an enzyme that turns inactive cortisone to cortisol and thus increases local levels of cortisol, which in turn can increase fat formation and thus increases in body fat.
So the answer to the cortisol dilemma is not to decrease cortisol levels in all parts of the body since normal levels of cortisol are vital to our health, but to decrease cortisol levels in fat tissue. And one of the most effective ways to do this is by decreasing the pro-inflammatory cytokines and subsequently insulin resistance, and thus the stimulus for increased cortisol levels.
LipoFlush Does It All
- Decreases levels of inflammatory cytokines, increases insulin sensitivity and decreases local cortisol production.
- Decreases fat absorption.
- Increases body fat breakdown or lipolysis, releasing fat into the circulation.
- Decreases fat formation, or lipogenesis (fat creation).
- Reverses the effects that cutting back on calories has on the body by normalizing thyroid hormone and metabolic rate, increasing the uncoupling of oxidative phosphorylation, and decreasing hunger.
- Suppresses appetite.
- Keeps your metabolism going 24 hours a day so that you lose and burn fat even while you sleep.
- Keeps energy levels high by correcting any metabolic dysfunction and optimizing energy and macronutrient cycles.
- Increases energy output by increasing heat production.
- Flushes fat from your body, and decreases the number of fat cells, much like liposuction.
- Increases fat excretion in the bowels, taking some of some of the dietary fat out of the equation.
- Increases energy and subsequently the burning of fat by optimizing mitochondrial function and increasing TCA cycle flux for maximum fat burning.
- Has no significant side nervous system, heart of increased blood pressure side effects.
- Preserves or even increases muscle mass. Subsequently enhances fat oxidation to supply the energy needed for protein synthesis and metabolism.
- Decreases homocysteine levels in the body and thus decreases the tendency to cardiovascular disease.
- Reduces levels of C-reactive protein, a measure of stress and inflammation in the body.
- Increases insulin sensitivity and decreases insulin resistance and the associated possibility of developing diabetes.
- Increases systemic levels of B12, folic acid and B6 to offset any deficiencies in these vitamins, leading to increased mental and physical energy and feelings of well being.
- Decreases cholesterol and triglycerides levels, while at the same time favorably affecting HDL (increasing) and LDL levels (decreasing).
- Increases calcium availability. Recent studies have shown that increased calcium, whether in the diet or by way of calcium supplements, results in lower body fat. LipoFlush contains over 400 mg of calcium in every dose.
The Bottom Line
LipoFlush represents a quantum leap in fat loss supplements. It's the first supplement that effectively decreases body fat by working at all the relevant metabolic, absorption and excretion levels, while at the same time providing substantial health benefits.
LipoFlush can be used by anyone who wishes to lose body fat. Most people who are just interested in losing weight while at the same time looking trim and toned will find LipoFlush ideal for them.
Athletes looking to maximize functional muscle mass and strength and minimizing body fat will find that LipoFlush is the perfect supplement to complement their training.
And bodybuilders looking to maximize muscle mass while taking body fat levels to the absolute minimum will find that LipoFlush is the perfect supplement to maximize their diet and training efforts, especially when in their cutting and pre-competition training phases.
The bottom line is that LipoFlush, with its unique emphasis on cutting edge research-based ingredients that target all of the pathways involved in weight and fat loss, and maximizing body composition, is by far the best fat loss supplement on the market today. If you question this statement compare the ingredients in LipoFlush with ANY OTHER product on the market today and you’ll be convinced.
So if you want maximum fat loss, maximum muscle retention, and a healthy and vibrant body and mind, then LipoFlush is the perfect supplement for you!
LipoFlush Nutritional Supplement Panel
LipoFlush and the Radical Diet
The Metabolic Diet, the Radical Diet, and the Anabolic Solution series of book, go hand in hand with LipoFlush. And several recent studies have shown that the Metabolic Diet (the basis for all my diets and programs) will help you lose body fat better than any other diet out there. For more information on LipoFlush and the research that backs it up, go to www.MetabolicDiet.com/pdfs/lipoflush_study1.pdf .
LipoFlush Works Synergistically with the Radical Diet resulting in fast weight and fat loss. It, as well as the rest of my MD+ line of supplements, are formulated specifically for my revolutionary phase shift diets.
The Radical Diet 2005, available in both soft cover book and ebook formats, is a very low calorie phase shift diet that is a quantum leap above all other diets. By changing you into a fat burning machine, the Radical Diet will help get the weight and fat off FAST, while at the same time preserving muscle.
Because the Radical Diet is streamlined to achieve one goal, fast weight and fat loss regardless of how much weight you have to lose, it has a no nonsense approach that is simple to follow and highly effective.
As well, the Radical Diet specifically targets abdominal fat and reigns in that spreading waistline in the first few weeks that you’re on the diet.
The Radical Diet Supplement Plans
The Radical Diet plans are available as beginners, intermediate and advanced plans. Each plan includes the Radical Diet eBook or book, and a number of supplements that work together to maximize fat loss and body composition.
Inflammation and the Radical Diet
As I’ve mentioned, there is a definite link between inflammation and both obesity and body fat, especially fat in the waistline area. There’s no doubt that adipose tissue secretes a number of adipokines that can adversely affect health.
As well, it’s my contention that the inflammatory process itself, likely a result of a combination of causes including some fat accumulation, aging, clinical and subclinical infections, stress and a host of others that all increase inflammatory levels in the body, begets an increase in body fat and eventually obesity, as well as a number of diseases including diabetes and cardiovascular disease.
It is also my contention that decreasing the inflammation, increases insulin sensitivity, decreases local cortisol production in fat, and ultimately makes it easier to lose weight and body fat. The interaction between inflammation, insulin resistance and body fat is certainly one of the mechanisms involved in the pathogenesis of weight and fat gain.
Although the exact cause and effect between insulin resistance, inflammation and obesity has still to be worked out, we do know that insulin resistance and elevated levels of cytokines go hand in hand. For example in a recent study lowering interleukin-6, one of the pro-inflammatory cytokines, improved insulin action in obesity.
LipoFlush is formulated to not only decrease inflammation, but also to work on other pathways with the goal of maximizing weight and body fat loss. Although it will work on its own, coupling it with the right kind of diet makes the whole process easier and faster.
The Radical Diet presents an optimal diet that works synergistically with LipoFlush, and also several other supplements in my MD+ supplement line.
The Radical Diet works because of a number of reasons, all explained in the book. However, one of the reasons is because it reduces inflammation in the body. A recent study looked at the adaptation that occurs to energy restriction at a molecular level and the benefits of very low caloric diets (VLCD) in humans and found it had beneficial effects on insulin resistance and inflammation.Sound familiar? If not re-read the section on inflammation and LipoFlush above.
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