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May-25-2011

MVM Version V

  MVM Version V

 

MVM is a comprehensive, specially balanced, multiple vitamin and mineral formula, with added ingredients, designed to promote body composition and athletic performance.

 

MVM – Advanced Evidence Based Formulation

 

MVM is the most complete multiple vitamin and mineral supplement on the market for anyone and especially for those who are interested in health, weight loss, body composition and athletic performance.

 

While the general medical consensus for the general population over the years was that you could get all you needed from food, that has changed – see the recent article “The Bottom Line” from the Harvard School of Public Health at Harvard Article.

 

The use of MVM is even more important for those who exercise, as we’ll point out below.

 

Highest Quality at a Reasonable Price

 

The list price of MVM doesn’t reflect the high quality and quantity of ingredients in MVM or the precision and care taken in its production. MVM is manufactured in a pharmaceutical grade facility that follows good manufacturing practices.

 

MVM is of such high quality that contamination with impurities is negligible since it’s as low as is commercially possible and definitely lower than most of our food supply, and contamination with ingredients not on the label is zero (something of concern to drug tested athletes). We make sure of that by running GC/MS analysis of each batch to ensure its quality and purity.

 

Couple that with the cutting edge evidence based formulation and it’s easy to see that MVM is a product that is of unparalleled quality and effectiveness, and guaranteed to have in it what’s on the label, and nothing else.

 

All the Important Ingredients and Much More

 

MVM contains all the vitamins and minerals deemed important for optimal health, and at levels that provide beneficial effects above and beyond amounts needed to deal with any frank and marginal deficiencies that may be present.

 

With its evidence-based approach, meaning that there are valid scientific and medical reasons behind the use of each of the ingredients in MVM, MVM is a supplement that caters to everyone in our modern day society, including the special needs of those looking to lose weight and body fat, and those involved in fitness, exercise, and athletic competition.

 

Besides the full complement of vitamins and minerals MVM also contains several nutrients that are felt to improve metabolism, decrease stress, and have anti-cancer and anti-aging properties (see table below).

 

 

MVM and Athletes

 

MVM is designed not only to safeguard overall health, but also to provide for the special needs that the athlete has for body maintenance, recuperation and repair. MVM supplies all the basic nutrients that may be depleted in those who exercise and is formulated to enhance the effects of training on body composition and performance.

 

MVM is so complete that you don’t have to worry if you miss some of your other performance vitamins once in a while because MVM will take up the slack in the short term.

 

For example, MVM contains high doses of Folic acid, Vitamin B6, Betaine and methylcobalamin, the biologically active form of B12 (not the cyanocobalamin, the synthetic and not as metabolically active form of B12 that is generally used), and increases energy and health.

There are supplements that cost more, including the various pak ones that spread their ingredients over several tablets in a marketing ploy to make them out to be more than what they really are, but there’s none on the market that’s better than MVM.

 

This group of ingredients has important effects on macronutrient metabolism, energy systems, and on combating the adverse effects of pollution and mercury toxicity. The health effects of all four of these ingredients have been extensively documented. Several of the medical parameters, such as homocysteine, cholesterol and C-Reactive Protein, markers of heart disease and inflammation in the body, are decreased by their use and by some of the other ingredients in MVM including the extensive number of antioxidants.

 

MVM is formulated to be the best vitamin mineral complex on the market regardless of price, and is especially useful for anyone who diets and/or exercises. Athletes who are concerned about body composition and performance will find MVM is ideally suited for them and the ingredients in MVM will help support their training and diet efforts.

 

For example many preparations don’t contain iron even in low levels. However, iron is important for many at least in minimal replacement doses, as in MVM, since it’s an important part of daily supplementation for who exercise.[1]

 

Also many preparations include beta carotene (as does MVM) but not vitamin A, assuming that any vitamin A that is needed by the body (for many functions including maximizing testosterone production and increasing insulin sensitivity) will come from the endogenous conversion of beta carotene to vitamin A. This is not necessarily the case. As such MVM contains 2000 IU of vitamin A and 10,000 IU of beta carotene – just to cover all the bases (see sidebar for more info).

 

MVM contains 400 IU of vitamin E, a level that I feel is necessary for athletes. Many of the other products, mainly because of expense contain about half that dose.

 

Athletes need high doses of the B vitamins, and again MVM has more than most preparations containing 100 mg of B3 and 50 mg of the rest.

 

Besides hefty doses of the all the necessary usual vitamins and minerals, in the most bioavailable forms, MVM contains a lot more ingredients to round out the formula and give you everything you could possibly need as a foundation for maximizing health, body composition and performance.

 

For example, MVM contains carnosine (a buffering agent and antioxidant that is implicated in both the muscle fibers that hypertrophy with resistance exercise and exercise performance, taurine, glutamine peptides, etc. that are targeted for athletes for improving muscle mass, strength and performance and maximizing body composition.

 

Recovery and repair of tissues require a host of vitamins and minerals that participate in synthesis of new cells and tissue, and providing these in supplement form can increase health and decrease disease.

 

For example, the body needs certain vitamins and minerals to make compounds that fight inflammation in the body, including  Vitamin B6, Vitamin E, Vitamin C, niacin, zinc, selenium and magnesium. Many vitamins and minerals also serve as antioxidants and help protect cells against the oxidative damage produced by inflammation. This can be seen in the beneficial effects of various individual vitamins and minerals in MVM, and in the synergistic effects seen among some of these nutrients.

 

Vitamin B12- The most expensive B vitamin in any product is vitamin B12. MVM has several times as much Vitamin B12 as most preparations. The usual form of vitamin B12 is called cyanacobalamin, a cheaper and synthetic form of B12. Cyanacobalamin is changed into the body to the active form of cobalamin in a reaction that strips off the cyanide molecule In MVM I use 500 mcg of the much more expensive metabolically active methycobalamin.

 

Vitamin A and Beta Carotene- As far as vitamin A there are a lot of misconceptions about its functions, metabolism and toxicity, and about the role of carotenoids.

 

Vitamin A is much more metabolically active than most people believe. Besides the common knowledge that it’s involved in eyesight, it also important for proper immune, gastrointestinal, musculoskeletal, and hormonal functioning, and for the utilization of protein. For example adequate body levels of vitamin A are important for testicular, ovarian, pituitary, and adrenal function, and for the production of testosterone and growth factors.[1]

 

Increased levels of vitamin A are necessary under conditions that deplete vitamin A reserves, such as high protein diets and chronic physically demanding exercise (as seen in any elite athlete), and any polymorphisms that affect the absorption, metabolism and utilization of vitamin A. There is also deficient intake in our society in those who diet to lose weight, minimize body fat, and maximize body composition.

 

The vitamin A issue is often misunderstood and while subclinical and clinical toxicities do occur, they’re not all that common even at therapeutic levels. Although vitamin A can cause liver damage but this damage typically occurs with daily doses of at least 25,000 units a day for a prolonged period of time.

 

Beta carotene has two roles in the body. It is a potent antioxidant and has beneficial effects on the immune system. As well, it can be converted into vitamin A if there is a marginal or frank deficiency of vitamin A.

 

Beta-carotene’s conversion to vitamin A in the body is limited by a feedback system. Supplementing the diet with beta-carotene does not produce any vitamin A toxicity despite its use in very high doses since it’s only metabolized to vitamin A as needed. With adequate levels of vitamin A in the system the feedback mechanism markedly decreases the already poor transformation of beta carotene into vitamin A, with the decrease being proportional to body levels of vitamin A.

 

 

MVM version V

 

Version V of MVM represents the ongoing improvement over more than a decade (Version I was formulated in 1997) of the best multiple vitamin and mineral supplement available anywhere.

 

As well as a full array of vitamins and minerals that surpasses any of the other multis, MVM also contains a variety of ingredients meant to enhance its effects on health, longevity, body composition and performance.

 

In keeping with the aim of maximizing health and meeting the needs of those who exercise and who are looking to improve body composition, the formulation for MVM has been improved, with more of some of the ingredients, such as vitamin D, folic acid, iodine, chromium, and over a few dozen new ingredients, including vitamin K, Digezyme, Bioperine, and a dozen or so ingredients, such as various plant extracts, and several that positively impact on health and metabolism.

 

Vitamin D

 

For example, vitamin D has been increased from 400 IU to 800 IU since it’s been shown we need more vitamin D than was once thought and that marginal deficiencies of vitamin D are common.

 

Vitamin D along with Calcium is intimately involved in skeletal homeostasis. But each does much more. Vitamin D has several vital functions outside this established role. Vitamin D has been shown to have important implications for general health, immunity, and cognitive function.[2],[3],[4],[5],[6]

 

As important for the athlete vitamin D is intimately involved in body composition, athletic performance, and risk of injury.[7],[8]

 

For more information on vitamin D see the first issue of my Elite Performance Newsletter at www.ElitePerformanceNewsletter.com.

 

Iodine, an important ingredient in the proper functioning of thyroid hormone has been increased to almost double the level in the previous version of MVM.

 

Vitamin K (as phytonadione) has been added as it’s been shown to maintain normal blood coagulation, decrease bone loss, maintain bone strength, and improve vascular health . It also may have roles in mitochondrial electron transport, protein synthesis, neuroprotection and immunity.

 

Digezyme™,an advanced plant enzyme complex, and Bioperine have also been added. Bioperine (an extract from piper nigrum, which increases nutrient absorption), and Digezyme ensures optimal absorption of the supplement ingredients as well as helping food digestion and assimilation.

 

MVM also contains several groups of ingredients not found in most multiple vitamin and mineral preparations. These ingredients add to the effectiveness of MVM, making it the most complete multiple vitamin and mineral formula on the market today, regardless of price.

 

Peptides and Amino Acids such as:

 

  • Carnosine
  • Glutamine Peptides
  • L-Glutamic Acid
  • L-Lysine
  • N-Acetly-L-Cysteine
  • Taurine

 

Herbal and Plant Ingredients and Extracts

 

  •  
  • Astralagus Root
  • Ginkgo Biloba Extract
  • Ginseng
  • Grape Seed Extract
  • Milk Thistle Extract
  • Panax Ginseng
  • Pine Bark Extract
  • Schizandra Berry Extracti
  • Silymarin
  • Spirulina

 

Special Ingredients for improving health and metabolism

 

  • Betaine
  • Choline Bitartrate
  • Citrus Bioflavonoids Complex
  • Coenzyme Q10
  • Fiber (both soluble and insoluble)
  • Hesperidin
  • Inositol
  • Lactobacillus Acidophilus
  • Lecithin
  • Lutein
  • Phosphatidylcholine
  • Rutin

 

Digestive and Absorption Aids

 

  • Bioperine® {Black Pepper Extract (Piper Nigrum)
  • DigeZyme™ (Aspergillus Oryzae)

 


MVM version V Supplement Panel

 

 

Exercise is Stress – How to Deal With It

 

No matter how you look at it, exercise is stressful to the body at the time exercise is done. But while it’s tough on the body, exercise is usually good for you in the longer term.

 

More importantly for the elite power and endurance athlete exercise is necessary for improving body composition and performance regardless of the sport, whether it be bodybuilding, where the concern is in maximizing body composition and muscle mass, or ultra-endurance sports where the emphasis is on performance.

 

During exercise the body copes with the wear and tear that exercise causes. There’s a dramatic increase in inflammation and in catabolism particularly in the musculoskeletal system. This is evidenced by the in catabolic pro-inflammatory cytokines such as Interleukins 1 and 6 (IL-1 and IL-6) and tumor necrosis factor alpha (TNF-alpha). I believe that in response to the inflammatory and catabolic changes there is a simultaneous increase in GH and IGF-1 and the endogenous anti-oxidant system.

 

After the trauma of exercise the body goes in repair, recover, and if the recovery is handled properly, super-compensation mode.

 

Elite power and endurance athletes who train hard and subject their bodies to what can be considered extreme stress need to look at both the exercise and post exercise phases in order to benefit from exercise as far as incrementally improving body composition and performance there is a need to intervene both during and after exercise.

 

During exercise

 

in order to  need to decrease the pro-inflammatory cytokines, increase the damaging effects of the excessive amounts of free radicals produced during exercise.

 

This is the main reason that athletes who train hard need to use antioxidants to help bolster endogenous antioxidant system. The use of antioxidants, in those that train hard, doesn’t compromise the endogenous antioxidant system but rather complements it so that counter productive excessive damage especially to membranes, mitochondria and genetic material, doesn’t occur.

 

And this is also the reason why I put elite athletes on Antioxas part of their foundation supplement regimen. And it’s also why I stress all three foundation supplements as a foundation for their athletic success.[9]

 


Laying the Foundation for Success

 

Antiox, along with MVM, and EFA+make up the Foundation Supplements.

 

These three lay the foundation for success in improving body composition and performance.

 

Introduction

 

Increasingly over the past few decades research is showing that supplementing your diet with vitamins, minerals, antioxidants, essential fatty acids and other ingredients can keep you out of harms way, help deal with certain diseases, provide a foundation for optimal health, and improve mental and physical performance.[10],[11],[12],[13],[14],[15],[16],[17],[18],[19],[20],[21],[22],[23],[24],[25],[26],[27],[28]

 

Some of these effects are due to correcting frank and marginal deficiencies while others are due to the beneficial effects of the nutrients themselves at higher than recommended daily intake.

 

Low intakes of various nutrients can lead to marginal deficiencies. Low intake is a problem in a significant proportion of athletes, especially those watching weight and body composition and thus do not consume sufficient amounts of many nutrients from foods alone. These deficiencies can be exacerbated by exercise since exercise can increase the need for certain nutrients.

 

For example, lower than normal intake of magnesium along with strenuous exercise that has been shown to increase the rate of magnesium loss via sweat and urine, can lead to a marginal deficiency. This in turn can impair energy metabolism, muscle function, oxygen uptake and electrolyte balance.[29],[30]

 

Some ingredients aren’t strictly necessary but help as far as providing benefits for improving body composition and exercise performance. For example, quercetin, which is present in my Antiox, has been shown to increase brain and muscle mitochondrial biogenesis and exercise tolerance, and thus may enhance athletic performance.[31]

 

Alpha lipoic acid (in Antiox and EFA+) has been shown to enhance insulin sensitivity, decrease post exercise lactic acid concentrations, and have potent antioxidant and anti-inflammatory properties.[32]

 

Many of the nutrients have multiple actions in the body. For example selenium also has significant anti-inflammatory properties.[33]

 

Exercise can lead to an increased need for certain nutrients. For example, one study found that there is an increase in selenium requirements with exercise.[34]Problems can arise from exercise induced mineral loss, which is further enhanced by the finding that many of us don’t consume adequate amounts of many essential minerals. Studies have shown that many athletes, and female athletes, in particular, consume diets that have been found to be inadequate for certain key minerals such as zinc, magnesium, copper, and iron. The combination of strenuous exercise and compromised mineral status ultimately leads to low endurance capacity, depressed immune function, and the development of a variety of disease conditions.

 

The bottom line is that anyone who exercises should be taking a good daily multiple vitamin and mineral supplement, to make sure that they’re not suffering from any marginal deficiencies, to make use of higher levels of certain nutrients that may offer physiological benefits, and as a preventative measure for some conditions and diseases.

 

There can also be marked health and in some cases treatment benefits to making sure you’re not marginally deficient in any of the vitamins, minerals, and fatty acids.[35],[36],[37],[38]For example low intakes of certain vitamins are associated with increased risk of certain cancers.[39]

 

The essential fatty acids are also necessary for optimal health as well as helping to maximize body composition and performance.

 

Overall, there is substantial evidence that the use of the three foundation supplements, MVM, EFA+, and Antiox can provide both short and long term benefits.

 

 

References:



[1]
Dubnov G, Constantini NW. Prevalence of iron depletion and anemia in top-level basketball players. Int J Sport Nutr Exerc Metab. 2004 Feb;14(1):30-7.

[2]Adams JS, Hewison M. Unexpected actions of vitamin D: new perspectives on the regulation of innate and adaptive immunity. Nat Clin Pract Endocrinol Metab. 2008 Feb;4(2):80-90.

[3]Ceglia L. Vitamin D and skeletal muscle tissue and function. Mol Aspects Med. 2008 Dec;29(6):407-14.

[4]Cannell JJ, Hollis BW, Sorenson MB, Taft TN, Anderson JJ. Athletic performance and vitamin D. Med Sci Sports Exerc. 2009 May;41(5):1102-10.

[5]Buell JS, Scott TM, Dawson-Hughes B, Dallal GE, Rosenberg IH, Folstein MF, Tucker KL. Vitamin D is associated with cognitive function in elders receiving home health services. J Gerontol A Biol Sci Med Sci. 2009 Aug;64(8):888-95.

[6]Kamycheva E, Joakimsen RM, Jorde R. Intakes of calcium and vitamin D predict body mass index in the population of Northern Norway. J Nutr 2003;133:102–6.

[7]Bartoszewska M, Kamboj M, Patel DR. Vitamin D, muscle function, and exercise performance. Pediatr Clin North Am. 2010 Jun;57(3):849-61.

[8]Hamilton B. Vitamin D and human skeletal muscle. Scand J Med Sci Sports. 2010 Apr;20(2):182-90.

[9]McAnulty SR, Nieman DC, Fox-Rabinovich M, Duran V, McAnulty LS, Henson DA, Jin F, Landram MJ. Effect of n-3 fatty acids and antioxidants on oxidative stress after exercise. Med Sci Sports Exerc. 2010 Sep;42(9):1704-11.

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[11]Grieger JA, Nowson CA, Jarman HF, Malon R, Ackland LM. Multivitamin supplementation improves nutritional status and bone quality in aged care residents. Eur J Clin Nutr. 2009 Apr;63(4):558-65.

[12]Carrero JJ, Fonolla J, Marti JL, Jimenez J, Boza JJ, Lopez-Huertas E. Intake of fish oil, oleic acid, folic acid, and vitamins B-6 and E for 1 year decreases plasma C-reactive protein and reduces coronary heart disease risk factors in male patients in a cardiac rehabilitation program. J Nutr. 2007 Feb;137(2):384-90.

[13]Hosli I, Zanetti-Daellenbach R, Holzgreve W, Lapaire O. Role of omega 3-fatty acids and multivitamins in gestation. J Perinat Med. 2007;35 Suppl 1:S19-24.

[14]Gaullier JM, Halse J, Hoivik HO, Hoye K, Syvertsen C, Nurminiemi M, Hassfeld C, Einerhand A, O'Shea M, Gudmundsen O. Six months supplementation with conjugated linoleic acid induces regional-specific fat mass decreases in overweight and obese. Br J Nutr. 2007 Mar;97(3):550-60.

[15]Mosley BS, Hobbs CA, Flowers BS, Smith V, Robbins JM. Folic acid and the decline in neural tube defects in Arkansas. J Ark Med Soc. 2007 Apr;103(10):247-50.

[16]Gariballa S, Forster S. Effects of dietary supplements on depressive symptoms in older patients: A randomised double-blind placebo-controlled trial. Clin Nutr. 2007 Jul 25; [Epub ahead of print]

[17]Hu J, Morrison H, Mery L, DesMeules M, Macleod M; Canadian Cancer Registries Epidemiology Research Group. Diet and vitamin or mineral supplementation and risk of colon cancer by subsite in Canada. Eur J Cancer Prev. 2007 Aug;16(4):275-91

[18][No authors listed] Folic acid. Good for brain health. Mayo Clin Health Lett. 2007 Jul;25(7):6.

[19]Nykamp D, Kavanaugh ED, Wenker AP. Vitamins: the wise choice for women with cardiovascular disease. Consult Pharm. 2007 Jun;22(6):490-502.

[20]Tipoe GL, Leung TM, Hung MW, Fung ML. Green tea polyphenols as an anti-oxidant and anti-inflammatory agent for cardiovascular protection. Cardiovasc Hematol Disord Drug Targets. 2007 Jun;7(2):135-44.

[21]Houston MC. Treatment of hypertension with nutraceuticals, vitamins, antioxidants and minerals. Expert Rev Cardiovasc Ther. 2007 Jul;5(4):681-91

[22]Machefer G, Groussard C, Vincent S, Zouhal H, Faure H, Cillard J, Radak Z, Gratas-Delamarche A. Multivitamin-mineral supplementation prevents lipid peroxidation during "the Marathon des Sables". J Am Coll Nutr. 2007 Apr;26(2):111-20.

[23]Simopoulos AP. Omega-6/omega-3 essential Fatty acids: biological effects. World Rev Nutr Diet. 2009;99:1-16. Epub 2009 Jan 9.

Simopoulos AP. The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Exp Biol Med (Maywood). 2008 Jun;233(6):674-88.

[24]Pawels EK, Volterrani D. Fatty acid facts, Part I. Essential fatty acids as treatment for depression, or food for mood? Drug News Perspect. 2008 Oct;21(8):446-51.

[25]Manhezi AC, Bachion MM, Pereira AL. The use of essential fatty acids in the treatments of wounds] Rev Bras Enferm. 2008 Sep-Oct;61(5):620-8.

[26]Leaf A. Historical overview of n-3 fatty acids and coronary heart disease. Am J Clin Nutr. 2008 Jun;87(6):1978S-80S.

[27]Simopoulos AP. The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Exp Biol Med (Maywood). 2008 Jun;233(6):674-88.

[28]Huang HY, Caballero B, Chang S, Alberg A, Semba R, Schneyer C, Wilson RF, Cheng TY, Prokopowicz G, Barnes GJ 2nd, Vassy J, Bass EB. Multivitamin/mineral supplements and prevention of chronic disease. Evid Rep Technol Assess (Full Rep). 2006 May;(139):1-117.

[29]Nielsen FH, Lukaski HC. Update on the relationship between magnesium and exercise. Magnes Res. 2006 Sep;19(3):180-9.

[30]Laires MJ, Monteiro C. Exercise, magnesium and immune function. Magnes Res. 2008 Jun;21(2):92-6.

[31]Davis JM, Murphy EA, Carmichael MD, Davis B. Quercetin increases brain and muscle mitochondrial biogenesis and exercise tolerance. Am J Physiol Regul Integr Comp Physiol. 2009 Apr;296(4):R1071-7.

[32]Kinnunen S, Hyyppä S, Oksala N, Laaksonen DE, Hannila ML, Sen CK, Atalay M. alpha-Lipoic acid supplementation enhances heat shock protein production and decreases post exercise lactic acid concentrations in exercised standardbred trotters. Res Vet Sci. 2009 May 7. [Epub ahead of print]

[33]Duntas LH. Selenium and inflammation: underlying anti-inflammatory mechanisms. Horm Metab Res. 2009 Jun;41(6):443-7.

[34]Margaritis I, Rousseau AS, Hininger I, Palazzetti S, Arnaud J, Roussel AM. Increase in selenium requirements with physical activity loads in well-trained athletes is not linear. Biofactors. 2005;23(1):45-55. Links

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[36]Bonjour JP, Guéguen L, Palacios C, Shearer MJ, Weaver CM. Minerals and vitamins in bone health: the potential value of dietary enhancement.. Br J Nutr. 2009 Jun;101(11):1581-96. Epub 2009 Apr 1. Links

[37]Evans JR. Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration. Cochrane Database Syst Rev. 2006 Apr 19;(2):CD000254.

[38]Newman KP, Neal MT, Roberts M, Goodwin KD, Hatcher EA, Bhattacharya SK. The importance of lost minerals in heart failure. Cardiovasc Hematol Agents Med Chem. 2007 Oct;5(4):295-9.

[39]de Vogel S, Dindore V, van Engeland M, Goldbohm RA, van den Brandt PA, Weijenberg MP. Dietary folate, methionine, riboflavin, and vitamin B-6 and risk of sporadic colorectal cancer. J Nutr. 2008 Dec;138(12):2372-8.

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